Comment · Thu, December 18, 2014 · Ceretropic
Bromantane and NSI-189 interactions?
Original post in this thread
Debonaire_Death · 10 points
I have both an order of Bromantane (from AwakeBrain) and an order of NSI-189 freebase (from TLR) on the way to my house, and I am already very excited to see if the bromantane could give the NSI-189 more smoothness, direction, and consistent energy.
But I've tried NSI-189 before, and I know it can be nasty with drug interactions. Has anyone had experience mixing these two chemicals? Are there any logically derived reasons that they wouldn't work out together in my brain chemically?
What they were answering
Debonaire_Death · 1 points
So I did some snooping around and found this link that seems to suggest there is definitely anticholinergic activity in bromantane. So,
In my experience, tobacco response on NSI-189 was potentiated; with bromantane in mice, it seemed to decrease nicotinic activity. So it would seem that, cholinergically at least, these drugs would counteract one another. I'll definitely be supplementing to raise acetylcholine levels.
What I'm more interested in is the other monoaminergic effects of both drugs working together. NSI-189 was definitely working with serotonin, as well as dopamine.
I'm theorizing that NSI-189 only modulates dopamine (as anyone found studies showing it's monoaminergic effects?) since it didn't seem to affect appetite whatsoever, whereas bromantine actually stimulates dopamine release. I think this could really reign in the difficulty with focus in NSI-189. Noradrenergic activity in bromantane wasn't siginificantly expressed at lower doses, so I doubt it will exacerbate NSI's anxiety symptoms. If I understand the reports of other users, it may mediate them.
Either way, so far it checks out! Can anyone else take a crack at this article (it's very short) and/or provide a good study on NSI-189 that would allow us to compare the neuromodulation and transmission activities of these two chemicals?
u/MisterYouAreSoDumb · Ceretropic
Supplementing choline will not make a difference if Bromantane is antagonizing the receptors. Honestly, there is not enough data on the mechanisms for each to comfortably say if they are safe together.