Does nicotine itself really causes tolerance?

Are Increased Gaba Receptors By Chronic Caffeine Intake A Good Thing?

Nicotine up-regulates nicotinic ACh receptors, but also desensitizes them. It's more complex than just up/down-regulation. Acutely, caffeine lowers GABAergic neurotransmission. [Inhibitory effect of caffeine on GABA-ac

Verdict on nicotine as a noot?

Replying to silverhydra · I noticed a nice little bit of ocular contracton (the area beside the eyes on the outside) when the gum is in my mouth, and then increased focus thereafter; haven't noticed anythin…

The notoriety is due to the fact that most people smoke tobacco to get it. Tobacco smoke contains harman and norharman, which are monoamine oxidase inhibitors. This increases the extracellular dopamine, serotonin, and no

What do you use to wake up?

We are going to come out with a Cytisine sublingual solution shortly. I usually chew nicotine gum in the morning. However, Cytisine feels more effective to me, and seems a bit smoother. Also, Cytisine has been shown to b

Why isn't DXM a more popular nootropic?

Replying to thelurkingdead · >Regardless, to be a nootropic, a substance has to be non-toxic. Says who? This is a great example of the type of uneducated armchair Pharmacology that goes on in this sub. The LD…

Call me an uneducated armchair pharmacologist all you want, but you are wrong! To be considered a nootropic, a substance must: >Exhibit few side effects and extremely low toxicity, while lacking the pharmacology of typ

Inflamed Liver from Nootropics

Replying to FW900 · EDIT: This is very unlikely as ND (where OP obtained all his nootropics) tests each batch and provides full transparency of the results. The same cannot be said for most supplement…

We have an ISO certified lab in-house, and test for contaminants in every single batch. We have a UPLC-MS, along with tons of other equipment that we use to test every single batch of material that comes into our facilit

E-cigarettes less addictive than cigarettes

Replying to relbatnrut · You joke, but nicotine is so much more effective as a nootropic with MAOIs (at least for me).

Ohh I know. It just also makes it more addictive.