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Comment · Thu, August 28, 2014 · Ceretropic

TLR sells 9-Fluorenone

Original post in this thread

mroing · 3 points

I noticed that TLR's website now identifies Eugerafinil-OA as 9-fluorenone. Does anyone have insight as to the effectiveness of 9-fluorenone, or know of any published research on it? Thanks.

http://teamtlr.com/tlr-oa-optimized-agents/37-eugerafinil.html

What they were answering

caronakid · 5 points

So does fluorenone oxidize into fluorenol because according to the cephalon study fluorenone was not a very effective wakefulness enhancer.

u/MisterYouAreSoDumb · Ceretropic

Wait, I had it backwards. Ours oxidizes into theirs. However, the studies show that theirs is less active than ours. 9-fluorenol oxidizes into 9-fluorenone in vivo, by breaking off the hydrogen from the hydroxyl group, making a ketone. So I have no idea why they went with a less active metabolite.

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