Comment · Fri, July 11, 2014 · Ceretropic
Vicodin + L-Theanine + Caffeine?
Original post in this thread
[deleted] · 0 points
I recently broke my thumb and was prescribed 5mg Hydrocodone/ 500mg APAP. I am currently taking 200mg of L-Theanine 20 minutes before a medium sized cup of black coffee and was wondering how the Vicodin will affect this stack.
1. Will the L-Theanine pronounce the effects of the Hydrocodone or will they work independently?
What they were answering
PurpleOrangeSkies · -1 points
Opioids are primarily GABAergic, whereas theanine is primarily dopaminergic; so, you there won't be much of a direct interaction. The extra dopamine from the theanine could possibly potentiate the euphoric effects of opioids, though. I'd be extra careful about any safety-sensitive task just in case.
u/MisterYouAreSoDumb · Ceretropic
L-theanine also affects the GABAergic system.
http://informahealthcare.com/doi/abs/10.1080/J157v06n02_02
Animal neurochemistry studies suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. In addition has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors.