Comment · Tue, January 28, 2014 · Ceretropic
Coluracetam Causing Depression?
Original post in this thread
sudojay · 9 points
I've read great things about coluracetam so I decided to try it out. I should say that I've been going through some difficult times personally but had been dealing with them okay. I've been using coluracetam at 15 mg twice a day and since I've been doing that my mood has gone from slightly down to borderline suicidal. When I've taken choline supplements in the past I felt roughly the same. Does it make sense that coluracetam could have the same effect? I realize this is confounded by my personal issues but I appreciate any input from people more educated on this topic than me. Thanks in advance.
What they were answering
sudojay · 2 points
I've been taking tianeptine for about 3 months and it's been really great for me. I just started the coluracetam a few days ago and that's when my mood dropped.
u/MisterYouAreSoDumb · Ceretropic
Ok, then it has to be your reaction to cholinergics. Some people just cannot have increases in their ACh levels. Since coluracetam increases the uptake of choline into the neuron to be converted in to ACh, that is likely the mechanism exacerbating your depression. It sounds like you just need to stay away from supplements that will increase choline of ACh levels.
I'm glad the tianeptine is working. It works awesome for me.