Comment · Fri, December 6, 2013 · Ceretropic
The Methylation cycle, Methylation analysis, and the 7 days you have left to get tested (cheaply) thru 23andme.
Original post in this thread
Rage_Boner · 82 points
It’s estimated that 45% of the population have a methylation cycle dysfunction. The [methylation cycle]( http://i.imgur.com/kRb0G3R.jpg) is one of the most important biochemical pathways in the body. It’s a chemical process that happens billions of times per second in our bodies and is responsible for many things, including:
* To produce vital molecules such as Co Q-10 and carnitine.
* To switch on DNA and switch off DNA. This is achieved by activating and deactivating genes by methylation. This is essential for gene expression and protein synthesis. Proteins of course make up the hormones, neurotransmitters, enzymes, immune factors and are fundamental to good health. When viruses attack our bodies, they take over our own DNA in order to replicate themselves. If we can't switch DNA/RNA replication off then we will become more susceptible to viral infection.
* To produce myelin for the brain and nervous system.
* To determine the rate of synthesis of glutathione which is essential for detoxification.
* To determine the rate of synthesis of glutathione which is an essential anti-oxidant as glutathione-peroxidase. Furthermore oxidative stress blocks glutathione synthesis - yet anot…
What they were answering
YoohooCthulhu · 1 points
23andme links to peer-reviewed papers regarding whatever SNP they are talking about
The issue is that peer-reviewed != clinically validated. Presenting such information to unsophisticated consumers who aren't familiar with that fact of medical literature leads them to believe these things are much more certain/clear cut than they are.
The burden of proof for publishing a paper on "gene x does y" in Nature Medicine is a lot lower than publishing a clinical trial showing "gene x predicts y disease".
u/MisterYouAreSoDumb · Ceretropic
Sure, I agree. However, they do state that the results should only be used as a resource, and that one's doctor is the final authority on treatment. Limiting the availability of a useful service because unsophisticated customers might get confused is wrong. If the FDA has an issue with specific wording, then address that individually. A blanket stop to all sales because morons don't do their own research and follow up with their doctor, is a setback to progress.