Comment · Tue, December 3, 2013 · Ceretropic
The Methylation cycle, Methylation analysis, and the 7 days you have left to get tested (cheaply) thru 23andme.
Original post in this thread
Rage_Boner · 82 points
It’s estimated that 45% of the population have a methylation cycle dysfunction. The [methylation cycle]( http://i.imgur.com/kRb0G3R.jpg) is one of the most important biochemical pathways in the body. It’s a chemical process that happens billions of times per second in our bodies and is responsible for many things, including:
* To produce vital molecules such as Co Q-10 and carnitine.
* To switch on DNA and switch off DNA. This is achieved by activating and deactivating genes by methylation. This is essential for gene expression and protein synthesis. Proteins of course make up the hormones, neurotransmitters, enzymes, immune factors and are fundamental to good health. When viruses attack our bodies, they take over our own DNA in order to replicate themselves. If we can't switch DNA/RNA replication off then we will become more susceptible to viral infection.
* To produce myelin for the brain and nervous system.
* To determine the rate of synthesis of glutathione which is essential for detoxification.
* To determine the rate of synthesis of glutathione which is an essential anti-oxidant as glutathione-peroxidase. Furthermore oxidative stress blocks glutathione synthesis - yet anot…
What they were answering
kant_go_on · 3 points
Point (2) being particularly worrying.
u/MisterYouAreSoDumb · Ceretropic
Every single page on 23andme links to peer-reviewed papers regarding whatever SNP they are talking about. They are merely aggregating known data into an easy-to-parse format, specifically tailored to your genetic results. The FDA is not calling into question the validity of the genetic tests. They are calling into the question the validity of the recommendations based on the results. However, 23andme gives you not only their analysis, but links to their reasonings and the ability to download the raw data to analyze yourself in things like Promethase.
Not to mention, people are ignoring the whole other side to the genetic testing: ancestry analysis. My mother was adopted, so I have no idea where half of my genetics came from. 23andme allowed me to get an idea of the regions my mother's side of the family was from. For $99, I got more than my moneys worth.