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Comment · Tue, October 1, 2013 · Ceretropic

Inhibitory effects of caffeine on hippocampal neurogenesis and function.

What they were answering

[deleted] · 5 points

[deleted]

u/MisterYouAreSoDumb · Ceretropic

If one also supplemented to prevent the down-regulation of TrkB, then it might help.

http://www.ncbi.nlm.nih.gov/pubmed/8752592

infusion of BDNF into the hippocampus of adult rats for 6 days produced an 80% decrease in levels of full-length TrkB protein. We thus show that exposure of hippocampal neurons to BDNF, both in culture and in the adult brain, results in down-regulation of TrkB. At least in vitro, this leads to long-term functional desensitization to BDNF, NT-3 and NT-4/5, as well as down-regulation of trkB and trkC mRNA.

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