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Comment · Sat, September 7, 2013 · Ceretropic

D-serine increases adult hippocampal neurogen... [Front Neurosci. 2013] - PubMed - NCBI

What they were answering

willonz · 3 points

I wonder if theres a risk of excitotoxicity being an NMDA agonist, or if theres a synergy with other NMDA modulators.

Anyone have an personal experience taking this as a nootropic?

u/MisterYouAreSoDumb · Ceretropic

There would definitely be a risk, as it is a full agonist. I've taken D-cycloserine, which is a partial agonist of the NMDA receptor. It gives me a weird buzz. I don't want to say excitotoxicity, but over-stimulation for sure. I have not played around with it too much, so I might just need to find the sweet spot. I might also try combining it with memantine, to prevent any damage.

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