Comment · Wed, July 24, 2013
Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.
What they were answering
[deleted] · 6 points
Thats interesting. I always figured the E cut with caffeine was the least harmful of adulterated pills.
u/MisterYouAreSoDumb
Well it is. That does not mean it's without interaction, because that is silly. Caffeine increases norepiniephrine in the body, which leads to increases in body temperature. Amphetamine does the same thing, but using a different mechanism. The same could be said for ephedrine, PMA, etc. The moral of the story is, keep your body temperature down.
However, if you are supplementing with alpha lipoic acid, MDMA induced neurotoxicity can be mitigated, even though body temperatures still rise. You can also have some THC, which helps regulate the body's temperature control systems.