Comment · Wed, July 24, 2013 · Ceretropic
Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men
What they were answering
[deleted] · 1 points
Then we need to take it in conjunction with something that can safely trigger natural repair mechanisms.
u/MisterYouAreSoDumb · Ceretropic
That would mean triggering eosinophils to the muscles. They are types of white blood cells that migrate to inflammatory regions in the body. They are what trigger rebuilding of the muscle fibers. They are produced in the bone marrow, and contain secondary granule proteins. They secrete interleukin type 4, which activates fibro/adipocyte progenitors (FAPs). Activation of the IL-4 signaling pathway in the FAPs starts myogenesis. This process also signals the FAPs to clear the necrotic debris left over from the cellular damage.
Without the eosinophils releasing interleukin type 4, the FAPs proliferate to adipocytes, which are what store fat rather than rebuild muscle. So that means without eosinophils, the muscle rebuilding and the clearing of damaged tissue does not happen. Without the inflammation, the eosinophils do not migrate to the region. This is why taking antioxidants can be counterproductive when working out, as they bind to the oxidative substances that cause inflammation.
So can we figure out a way to get eosinophils to migrate to the muscle fibers without an inflammatory response? I am not sure.