Long-term behavioral and biochemical effects of an ultra-low dose of Δ9-tetrahydrocannabinol (THC): neuroprotection and ERK signaling.

Would you rather choose Noopept or Lions mane 8:1 in terms of NGF and motivation, or there is some third better option?

Replying to GettinWiggyWiddit · Yes but I secretly don’t want everyone jumping on this train 🤫 would hate for it to go out of stock haha

Ironic that you are replying to someone named /u/DoNotBeSelfish. LOL

Nootropics Depot: Mushroom Extracts!

Replying to QuantumLife · Do all of those extracts take multiple weeks to see their effects? (like Lion's Mane)

No. Lion's Mane is a neurogenic one. Neurogenic compounds usually take time to affect the brain. Think of how Semax, Selank, or Noopept build over time. Other mushroom extracts have immediate effects on things like: impr

Need some help understanding a NAC experience I had

Replying to AwkwardHand · Thank's for the response, I wasn't taking benzos/amphs for 2 years when that happaned. Could you recommend some noots that would be worth a shot in my case? I'm taking bacopa/ash a…

Ohh, it sounded like you had recently quit the benzos and amphetamine. 2 years should be enough time to get back to normal, but they can have some long-lasting effects that linger. >What I want to give a shot now is alp

Selank Review

Replying to PubliusPontifex · I agree it's too much BNDF, it feels that way (reminds me of when I was a child and felt similarly foggy, before then I had a near-photographic memory). The semax was the 1% stuff,…

Actually, now that I think about it, I have been noticing some BDNF issues the past week with my normal 1.3mg dosage. Perhaps the dosage needs to be lowered as time goes on, similar to noopept. We are going to be offeri

Amphetamine and dopamine receptors

Tolerance is not the same thing as neuronal damage. Damage can cause tolerance, but tolerance does not necessarily mean damage. Most amphetamine tolerance comes from immediate active gene expression, and the down-regula

Why not meditate?

Replying to octousan · Well that was well said and I have little to add. Except that we do at least somewhat understand which brain regions are activated and how that differs depending on the type of med…

I would agree. However, it seemed OP was asking why we were even seeking substances at all, if we had meditation. My point was that, given our current abilities, chemical substances allow us to get closer to understandin