Comment · Fri, May 31, 2013 · Ceretropic
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation.
What they were answering
[deleted] · 10 points
Oooh, dunno that I'd want to be on either of those - the former being an SSRI (hello sexual dysfunction!) and notorious for side effects... not fun, or even a nootropic. Cool to see that, though.
Desipramine I hadn't heard of until just now (I know the SSRIs better than the TCAs, I guess I'm a product of my time), but a quick glance at the wiki page cites it to be genotoxic (not fun). However, it's said to be more potent in norepinephrine reuptake inhibition than serotonin, probably leading to more typical NRI than SRI side effects. Neat.
["[..] chronic inositol induced a significant increase in striatal D(2) receptor density (B(max)) with a slight, albeit insignificant, increase in 5HT(2) receptor density."](http://www.ncbi.nlm.nih.gov/pubmed/11267629)
Cool stuff. But this study was on guinea pigs, dosed at (1.2 g/kg). Not sure what the conversion rate is, but that's a hell of a lot (roughly the dosage used to treat OCD, I'm guessing, since the abstract discusses OCD as well). It's a sugar alcohol, your body might not digest it, or if it does, it might not digest it well, leading to gas/bloating/cramps. This occurs most often at higher doses. I took 4 grams the other day just for the hell of it. Roughly 20 hours later (reasonable time), I got some wicked gas. It's the only thing from my memory that I did differently in those days, so I'm pretty confident that's what ca…
u/MisterYouAreSoDumb · Ceretropic
Yeah, high doses of inositol would work too. I wouldn't want to be a fart factory, though. It sounds like you are enjoying your caffeine buzz!