Comment · Sat, April 20, 2013 · Ceretropic
Modafinil Tolerance: Possible Modes of Action
Original post in this thread
cretan_bull · 59 points
I've recently started taking Modafinil for its nootropic and eugeroic effects; and was interested in anecdotal reports that long-term use leads to tolerance and decrease, or cessation of effectiveness.
A Google search for "modafinil tolerance" produces many dozens of blog posts, forum comments etc., of people reporting building tolerance or wondering how to reduce the effects of tolerance.
However, searches of PubMed or Google Scholar do not produce any substantive results on the matter. I have been unable to find any publications mentioning tolerance, except to say it is "well tolerated" toxicologically.
As a practical matter, I am interested in the following question:
Is this tolerance effect real? If so, under what conditions does it appear and can it be mitigated by appropriate dosing; supplementation with other drugs; or otherwise?
At this point, I would like to mention that I do not have a background in pharmacology, only that I have spent a few hours researching and synthesising the literatur…
What they were answering
Vaenomx · 3 points
Not only would I go with black pepper, I would capitalize on the opportunity and throw Curcumin in the mix: the trouble with Curcumin is that it needs piperine to be absorbed significantly. (so nerd)
"Preliminary studies indicate that curcumin may have a positive effect on neurogenesis in the hippocampus and may increase levels of brain-derived neurotrophic factor (BDNF) in rats."
"A curcumin pyrazole derivative was found to improve memory and was neuroprotective, stimulating BDNF in vitro and in vivo.[33][34] The compound was found to be protective in animal models of brain trauma and stroke.[35][36]"
u/MisterYouAreSoDumb · Ceretropic
Yeah, I assume you read through that Longecity post on it?