Comment · Fri, April 12, 2013 · Ceretropic
Hey r/Nootropics, we are two neuroscience grad students looking for your suggestions on an upcoming project.
Original post in this thread
Cerebrosaur · 45 points
As the title says, we are two neuroscientists looking for some advice on a project we are undertaking. We find drugs fascinating, so we are starting a blog about drugs for people that love drugs too.
We will be scouring journals and reporting on any interesting research we come across. We hope to break down papers so they're easy to understand while still keeping it intellectually stimulating.
We're curious what topics you would like to hear about, and if you have any suggestions for us we would love to hear them!
Edit: Thanks everyone for all the great ideas and suggestions. We are moving ahead with the blog, and once we have it up and running we'll be back here to let you all know. We'll be continuing to check on this thread, so feel free to continue discussing! If I get some free time (trying to wrap up thesis ATM, reddit is not conducive to that) I'll try and come back to address some questions people had.
What they were answering
Vaenomx · 1 points
I just somehow lost a lengthy reply I wrote you and don't have any clue as what happened. It's too late for me to type it all over so I'll make it super to the point; sorry :(
Study 1 - Read the abstract again: E2 induced both upregulated effect on TPH and SERT. E2 did just as well as E2 + Flx. It was done on Ovx rats.
Study 2 - Bad design and proven either wrong or irrelevant. RBL-2H3 cells are Mast cells which are not even good model for Mast cell research, let alone neurons. So it was a study done in vivo on something irrelevant to depression or anxiety.
Study 3 - By the same Koreans institutions and some researchers from study 1. This time in vivo and more rationnal, yet reeks of confirmation bias:
A few of the researchers of Study 2 and 3 published a paper in 2012 in which it reports that fluoxetine - in rats - 14-3-3 upregulates, that 14-3-3 and TPH are colocalized but that TPH wasn't found to be upregulated in any of the regions studied. So they basically confirms study 1 was bad and that study 2 was possibly bad and/or driven by confirmation bias. I had to read 3 time that abstract to make sure they were indeed no TPH upregulation, but yep.
I feel that many subjects are more deserving of our attention than this specific one. Let's not lose more time on that. I agree that the answer isn't settled if you tell me how you do those nice lines in your comments. :)
u/MisterYouAreSoDumb · Ceretropic
Fair enough. I'm sick at the moment and definitely not being as detailed as usual. I'll do some more searching when my brain is working again. Haha
To make a line, just put a bunch of these _ in a row.