Comment · Fri, April 12, 2013 · Ceretropic
Hey r/Nootropics, we are two neuroscience grad students looking for your suggestions on an upcoming project.
Original post in this thread
Cerebrosaur · 45 points
As the title says, we are two neuroscientists looking for some advice on a project we are undertaking. We find drugs fascinating, so we are starting a blog about drugs for people that love drugs too.
We will be scouring journals and reporting on any interesting research we come across. We hope to break down papers so they're easy to understand while still keeping it intellectually stimulating.
We're curious what topics you would like to hear about, and if you have any suggestions for us we would love to hear them!
Edit: Thanks everyone for all the great ideas and suggestions. We are moving ahead with the blog, and once we have it up and running we'll be back here to let you all know. We'll be continuing to check on this thread, so feel free to continue discussing! If I get some free time (trying to wrap up thesis ATM, reddit is not conducive to that) I'll try and come back to address some questions people had.
What they were answering
Vaenomx · 1 points
You and me both. I fear the science to deliver the specifics hasn't been done and won't before a long time.
Btw, Fluoxetine and Citalopram (as some other antidepressants) have both been shown to downregulate TPH. As for SERT, they both downregulate and internalize it. Valenfaxine doesn't.
EDIT: Paper about Fluoxetine on SERT; Internalization and degradation, but not clear mention of effect on the modulation of expression of the protein.
So, Bacopa upregulates both TPH and SERT, while FLUO/CITO downregulate both SERT and TPH. Interesting. Now I wonder what else upregulates both TPH and SERT.
u/MisterYouAreSoDumb · Ceretropic
This study showed that fluoxetine up-regulates TPH and apparently the SERT in the dorsal raphé.
Furthermore, E2 and E2 + Flx similarly upregulated the mRNA expression of serotonin reuptake transporter (SERT) and tryptophan hydroxylase-2 in the dorsal raphé of Ovx rats, while having no effect on SERT expression in the frontal cortex, hippocampus, septum, amygdala and periaqueductal gray.
_________________________
This study also shows increased TPH expression due to fluoxetine.
In this study, the expressions of the 14-3-3zeta gene and the protein were up-regulated at 72 h. In addition, the increase of TPH mRNA was observed at 12, 24 and 72 h in the fluoxetine-treated RBL-2H3 cells. We conclude that fluoxetine induces increases of 14-3-3zeta mRNA, 14-3-3zeta protein and TPH mRNA at 72 h in the RBL-2H3 cells.
______________________
Here is another study that showed TPH up-regulation.
>hese data demonstrate
that in addition to the known short-term action as an uptake
blocker, sertraline also exerts a long-term effect on the seroto-
nin neurotransmission by enhancing serotonin synthesis. A
similar effect was observed with another SSRI, fluoxetine, but
not with the non-SSRI chlorpromazine.
______________________________________
So it looks like there is conflicting evidence as to whether it up-regulates TPH. It also looks like it up-regulates the SERT, but only in the dorsal raphé. I am curious as to what mechanism they are using achieve this effect.