Comment · Thu, March 21, 2013 · Ceretropic

Has anyone experimented with Centrophenoxine as an alternative acetylcholine supplements in their stack?

Original post in this thread

dangling_participles · 6 points

I was watching this vedeo about Centrophenoxine use as a nootropic, and they mention as a precaution that it is an effective cholinurgic enhancer. So instead of introducing more acetylcholine into the brane it improves uptake. The caution is that excessive acetylcholine can cause headaches and muscle cramps. I'm assuming then that one would not want to mix Centrophenoxine with any of the choline supplements.

What I'm wondering though, is if this would be as effective when paired with a racetam as choline supplements are supposed to be. Another possibility is that it would have a synergistic effect when combined with piracetam and a choline supplement since piracetam is supposed to deplete acetylcholine. I would probably want to be careful about dosing though. Or am I totally overestimating the strength of these supplements?

What they were answering

[deleted] · 3 points

i replaced cdp with centro for a while - a month or so, maybe a bit more i wasn't counting.

centro is a better version of DMAE, both eventually breaking down into acetylcholine - if i'm not mistaken. it's also supposed to be somewhat stimulating and better for memory - but why i'm not sure... if someone can provide some insight on the specific reason for this?

anyways, i just took 30mg noopept + 4.8g pira and coincidentally i forgot to take any choline (as mentioned i would usually take centro) and i feel fine. wonder if it has anything to do with centro?

u/MisterYouAreSoDumb · Ceretropic

DMAE does not break down into ACh. It is an ACh analog. It takes the place of ACh in the brain.

http://jpet.aspetjournals.org/content/200/3/545.short

Regardless of deanol pretreatment time (1-30 minutes) or doses (33.3-3000 mg/kg i.p.) used, we detected no increase in mouse whole brain ACh levels. Likewise, there was no detectable elevation in ACh levels in rat whole brain, cortex, striatum or hippocampus after a 15-minute pretreatment with 550 mg/kg of deanol (i.p.).

_____________________

http://www.sciencedirect.com/science/article/pii/S0031698977800672

Ch administered i.p. or i.v. up to the dose of 120 mg/Kg caused neither behavioural effects nor changes in ACh level. Similarly no effects were detected following administration of equimolar doses of PCh or DMAE.

______________________

http://jpet.aspetjournals.org/content/211/3/472.short

Treatment of rats with [2H6]deanol significantly increased the concentration of choline in the plasma and brain but did not alter the concentration of acetylcholine in the brain.

So it's effects are different to an ACh precursor. It's other effects are postulated to be from it's ability to scavenge reactive oxygen species and protect cell membranes and increase their fluidity.

Other MYASD lines in this thread

Comment · Thu, March 21, 2013 · 1 pts
If choline levels are an issue with you, then I would suggest a choline precursor with your DMAE or centro. For me, it's not an issue. I never get any choline deficiency headaches, so DMAE should be fine on it's own. I h

Related in the archive

Commentr/NootropicsAug 15, 2013r/Nootropics yearsCeretropic

Will heat or acidity degrade noopept? (can I put noopept in my morning cup of coffee?)

Noopept's melting point is 97*C (206*F). That is less than boiling, which is what most people use for coffee. So I would not suggest putting it in boiling water. I'd be worried about stomach enzymes too. Oral administra

17NoopeptDosingPeptides

Commentr/NootropicsJan 22, 2014r/Nootropics yearsCeretropic

Noopept in hot beverages?

Noopept's oral bioavalability is around 10% in comparison to IV administration. [Bioaccessibility of the new dipeptide nootropic drug noopept](https://mega.co.nz/#!sJZEmCzJ!Q5VNgBHRLbEDl9Tz6jSUDGgZrflox09TJivWIoa_CDg)

11NoopeptDosingPeptides

Commentr/NootropicsAug 29, 2013r/Nootropics yearsCeretropic

Noopept- 1 Week Check-In

Replying to GetsEclectic · > First problem was, not taking it under the tongue, won't work at all unless you do. This is not true, noopept has high oral bioavailability. http://en.wikipedia.org/wiki/Noope…

Noopept has low oral bioavailablity. Around 10% to be exact. Don't cite Wikipedia. I just changed the entry. Oral administration of noopept reaches much lower plasma concentrations than IV and sublingual. A lot of peopl

11NoopeptDosingPeptides

Commentr/NootropicsFeb 1, 2019Nootropics DepotNatrium Health & Nootropics Depot

Nootropics Price Comparison Index

You don't account for dosage of capsules. So the price values of those are all inaccurate. Take noopept for example. We are by far the cheapest per mg in capsules. We just sell it in 30mg and 10mg amounts. Also, multiple

9NoopeptPiracetamPhenylpiracetamL-theanine

Commentr/NootropicsJun 10, 2016Ceretropic eraCeretropic & Nootropics Depot

Sublingual noopept with tablets?

Replying to 112358134 · :/ This is what happens when people decide to ignore the valid information and instead read many times anecdotal references of those who for well-known reasons decided to believe t…

I get that you really just want to defer to Russians companies without evidence, but to say there is no evidence that the oral bioavailability of Noopept is low, is ridiculous. The Russian studies themselves are where I

8NoopeptDosingPeptides

Commentr/NootropicsJun 25, 2020Nootropics DepotNatrium Health & Nootropics Depot

Why do capsules always seem to be dosed to the max?

We offer noopept in 10mg and 30mg capsules. The sample pack is the 30mg, but that's the most commonly bought. The vast majority of people out there are getting the 30mg ones. 3mg is insanely low for most people. We can't

7NoopeptAniracetamL-theanineDosing