Comment · Wed, January 22, 2014 · Ceretropic
Noopept in hot beverages?
Original post in this thread
dubyrunning · 4 points
I'm just wondering if anyone knows how well Noopept holds up in a hot beverage like coffee. I know that sublingual bioavailability is better, but from what I've heard, Noopept's oral bioavailability is still respectable. My question is whether or not the heat of the coffee would denature the peptide. Does anyone know?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
Noopept's oral bioavalability is around 10% in comparison to IV administration.
Bioaccessibility of the new dipeptide nootropic drug noopept
The absolute bioaccessibility was on the average AUC p.o./ AUC i.v. = 9.33 +-1.30%, which is evidence of a pronounced effect of the “first passage” via the gastrointestinal tract and the liver. In comparison with rats, rabbits are characterized by slower absorption of the parent substance, which is manifested by an almost twofold increase in MRT and by decrease in the C max AUC 0 ratio in the latter case.
This means that you will have to take a much lager dose orally to get the same effects as sublingual or injection. The Russian studies on the matter also mirror the findings that you need to take 10 times the amount orally as parenteral.
Similar plasma level of GVS- 111 was observed after 5 mg/kg parenteral and 50 mg/kg oral administration.
Also, they found:
Considerable differences related to the administration route were revealed in GVS-111 metabolism. After parenteral administration, apart from the unchanged GVS-111 molecule, the plasma contained 2 phenylacetyl metabolites phenylacetylproline and phenylacetic acid, which were not detected after oral administration. At the same time, plasma chromatograms after oral administration showed a peak which was eluted before GVS-111 and differed from the known phenylacetyl-derivatives by the elution time. It could be either hydroxylated or methylated GVS-111 metabolite. This difference in GVS-111 metabolism in different administration routes seems to be due to the fact that parenterally administered peptide is hydrolyzed preferentially by plasma peptidases, while metabolic transformations after oral administration occur during its first passage through the liver.
So we know that most of the noopept dosage is ripped apart by digestive enzymes. Adding it to hot liquid may reduce it even further, depending on what is in the liquid. I would assume that a little more would be lost by adding it to hot coffee.