Comment · Wed, March 13, 2013 · Ceretropic
Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice
What they were answering
Direct reply to the original post in this thread.
u/MisterYouAreSoDumb · Ceretropic
Very interesting! It looks like it was a result of increased AMPA receptor expression, due to increased TNF-alpha production.
>Thus, TNF
a
released by human glial cells
(
Figure S4
A,
Figure 5
C) enhanced host neuronal fEPSPs by
increasing the number of functional postsynaptic GluR1 AMPA
receptors (
Figure 5
C), and conversely, thalidomide suppressed
plasma membrane insertion of AMPA receptors, but not NMDA
receptors, by inhibiting TNF
a
production