Comment · Sat, March 9, 2013
Why does Grapefruit Juice potentiate so many different drugs?
Original post in this thread
naefunk · 16 points
From morphine and ketamine all the way to caffeine; how come this is the case?
I've heard that white grapefruit juice is best and that juice from concentrate is even better.
Is this something which has been isolated and made available as a supplement / whatever it would be?
What they were answering
GetYoHandsOffMyKicks · 1 points
Is this in addition to or the cause of dopamine uptake into the 5-HT receptors? Or do you not support that idea?
Also, are you aware of any research that suggests there may be long-term damage from MDA? I only ask because I'm quite interested in using MDA alone or in combination with MDMA.
If you answer, thanks!
u/MisterYouAreSoDumb
I do not really support that idea. Can it happen? Sure. However, it's not the cause of the widespread 5-HT system toxicity we see from MDMA use. The only way researchers can create the same type of toxicity seen with MDMA use is to inject certain MDMA metabolites. There are many drugs that deplete serotonin and increase dopamine that do not cause the 5-HT system damage MDMA does. Hell, even MDA and MDMA injected directly in the brain do not cause the damage. If dopamine were to blame, then it would have led to MORE toxicity, not zero.
MDA is very neurotoxic, that is for sure. If you can figure out a way to inhibit CYP2D6 and prevent MDA from ring-hydroxylating, then you can stop that toxicity as well. Or you can just load up on a bunch of antioxidants to bind to the damaging substances once they are made.