Comment · Sat, March 9, 2013 · Ceretropic
Phenylpiracetam potential as an antidepressant?
Original post in this thread
_julain · 13 points
I've been using phenylpiracetam on and off for a few weeks, ~100mg sublingually, and I've noticed that aside from an increase in energy, it seems to lift my mood. I don't feel manic, elated, or any of that, I just feel good. I took ~100mg 3x today to combat my MDMA comedown and I've felt essentially normal all day. I've also used it to completely eradicate alcohol hangover symptoms (mainly the depressed, apathetic state they leave me in). Has anyone ever looked into phenylpiracetam as an antidepressant? Is there enough known about the compound to have any idea how it could improve my mood? I've heard other people report the same thing.
What they were answering
_julain · 2 points
Very interesting. Have you ever tried DMAE? It looks like it might do some interesting things in the brain (it looks like DMAE can cross the BBB, just not the choline produced in the liver due to the charge?)
u/MisterYouAreSoDumb · Ceretropic
I have not tried it. It can cross the BBB, but the choline conversion happens in the liver. Choline cannot cross the BBB itself. So for it to raise ACh levels in any meaningful amount, it would need a way to be methylated in the brain. Perhaps taking a methly donor supplement like SAMe or trimethylglycine could help.