Comment · Thu, March 7, 2013 · Ceretropic
Modafinil Posts
Original post in this thread
MisterYouAreSoDumb · 239 points
Lately this subreddit has been turning into "Modafinil and Me." This is a place to advance our knowledge of all nootropics, not simply beat the latest popular one to death. I understand that many of you have questions about modafinil. However, I assure you that they have all been answered before. The search function works well, please use it before asking basic questions that we have all seen 100 times. I do not want to discourage discussions. However, we should limit those discussions to trying to expand information, not regurgitate what we already know.
* Modafinil is a wakefulness promoting agent.
* Modafinil will not replace dopaminiergic stimulants for ADHD.
* Modafinil will not work for everyone.
* Both enantiomers in racemic modafinil are active.
* R-modafinil is 3 times more active.
* Generics seem to be hit or miss. Some think they are the exact same, other don't...
* Your order will take a while to get here. Don't ask us if this is a normal thing.
* Modafinil increases hypothalamic histamine. This can lead to flush-like symptoms.
* There is a 99.999999% chance that you do not have Steven Johnson's Syndrome. If you did, Reddit is not the place to figure that out.…
What they were answering
Winslow_Strong · 2 points
I'm currently reviewing the use-case for modafinil. I'm writing it all up and will make my findings public when done.
Mister - thanks for sharing that new study on relative binding of S-/R-moda to DAT. I had previously only seen their relative activities commented on in this 2010 study that claimed:
"The R-and S-isomers are equipotent, producing equivalent pharmacologic activity at equal concentrations." https://www.ncbi.nlm.nih.gov/pubmed/21118743
However, the only reference they site is modafinil's prescribing info (http://www.provigil.com/media/PDFs/prescribing_info.pdf) (current Dec 2010), from which the only relevant statement seems to be:
"The optical enantiomers of modafinil have similar pharmacological actions in animals."
I wonder if they will revise the label, or if somehow a factor of 3x is still within the realm of "similar"
u/MisterYouAreSoDumb · Ceretropic
That's a pretty big oversight on their part. I wish I could say I am surprised. If they have not proven the pharmacology, then they should not make the statement.