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Comment · Wed, November 28, 2012

How efficiently will my brain recover after amphetamine use?

Original post in this thread

Boobs_and_Hot_Cakes · 8 points

I recently saw a post on bluelight in regards to the regeneration of serotonin receptors following MDMA use, that same post claimed that dopamine production/receptors do not return to normal levels following methamphetamine abuse.

I use dextro-amphetamine at therapeutic doses on a regular basis, usually about 60-90mg a week. I was curious what level of damage this is doing and whether or not this damage is repairable.

Extra information

Exams are over so it's been about 10 days since my last dose, I'm not extensively addicted, I'm still able to do chores and accomplish tasks though slightly less efficiently and I do feel less inclined to socialize. I've been taking amphetamine for about 18 months and have a further 5 years left of university which I would consider using it for, at a decreased dosage of about 40-60mg a week.

What they were answering

Cannibalsnail · 1 points

Yep. Metabolizes to GHB which has a dopaminergic rebound period.

u/MisterYouAreSoDumb

Ok, just making sure. GBL is weird because it's one of the only pro-drugs I know of that has faster onset than it's metabolite (GHB), due to it's lipid solubility. I find that interesting. I've never tried either of them though.

Be careful with them. I know they reduce the expression of your calcium channels as well as causing oxidative stress.

Subjectively, what does GBL/GHB feel like?

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