Comment · Wed, November 28, 2012
How efficiently will my brain recover after amphetamine use?
Original post in this thread
Boobs_and_Hot_Cakes · 8 points
I recently saw a post on bluelight in regards to the regeneration of serotonin receptors following MDMA use, that same post claimed that dopamine production/receptors do not return to normal levels following methamphetamine abuse.
I use dextro-amphetamine at therapeutic doses on a regular basis, usually about 60-90mg a week. I was curious what level of damage this is doing and whether or not this damage is repairable.
Extra information
Exams are over so it's been about 10 days since my last dose, I'm not extensively addicted, I'm still able to do chores and accomplish tasks though slightly less efficiently and I do feel less inclined to socialize. I've been taking amphetamine for about 18 months and have a further 5 years left of university which I would consider using it for, at a decreased dosage of about 40-60mg a week.
What they were answering
Cannibalsnail · 5 points
Selegiline is heavily contraindicated with Amphetamine. This is extremely reckless advice.
u/MisterYouAreSoDumb
I'm sorry, but if you are going to attack my suggestion, please explain your reasoning and give sources.
Selegiline is a selective MAO-B inhibitor. I has been shown to be neuroprotective by inhibiting the metabolism of dopamine to hydroxyl radicals.
http://www.ncbi.nlm.nih.gov/pubmed/16490285/
http://www.ncbi.nlm.nih.gov/pubmed/7538579
http://www.ncbi.nlm.nih.gov/pubmed/11958519
http://www.ncbi.nlm.nih.gov/pubmed/14636968
These results indicate that selegiline can be used safely even in combination with methamphetamine, as the cardiovascular effects of the drug combination were no greater than either drug alone, and were actually reduced at the higher selegiline dose.
If you have some insight into this, by all means add to the discussion. All my research shows that it is neuroprotective to DA and 5-HT neurons by preventing dopamine being turned into hydroxyl radicals by MAO-B.
Will you have to lower your amphetamine dose? Perhaps. However, that's a win/win.