Comment · Tue, November 13, 2012 · Ceretropic
Is it better to focus on NGF promoting nootropics rather than racetams? I would think growing nerves would be somewhat of a permanent result?
Original post in this thread
HiyaGeorgie · 7 points
Not to say you have to choose one nootropic over the other but Noopept and Lion's Mane for example promote NGF, obviously with some data conflicting this as with anything, but it's a start. Do I have the wrong idea of NGF in thinking that newly grown nerves would stick around after drug use is discontinued to a certain extent where as piracetam type gains would rely heavily on the drug actually being active in your system?
What they were answering
HiyaGeorgie · 1 points
I'm wondering about people who have done a lot of recreational drugs including ecstasy and are "damaged" which may be similar to being old in this sense?
u/MisterYouAreSoDumb · Ceretropic
What type of "damaged" are you referring to? Are you referring to axon terminal destruction? That usually only happens with heavy MDMA use. However, NGF and BDNF would be the appropriate course to try and regrow the connections. There is also the more common damage of lowering the effectiveness of your gated calcium channels. This happens far more than axon terminal destruction. To rectify this, use of substances like memantine, or NMDA positive allosteric modulators like piracetam would be more appropriate. Then there is the serious one, neuronal death. Once a neuron is dead, there is no bringing it back; not yet anyway. In the central nervous system, the neurons are sheathed in myelin and oligodendrocytes. Once total death occurs, the left over debris does not get broken down as easily, creating a region that new neurons cannot grow across. Also, since the neuron has been completely destroyed, NGF and BDNF expression will not help. So how damaged are we talking here?