Comment · Mon, November 5, 2012 · Ceretropic
Piracetam and psychostimulants
Original post in this thread
gannons · 23 points
http://www.sciencedirect.com/science/article/pii/S030698771200206X
So from what im reading hear is the Piracetam increases the effects of MDMA and Meth. Could one safely say that you would notice an increase effect of Ritalin while on piracetam?
What they were answering
newworkaccount · 3 points
Absolutely. To be honest, my guess is that piracetam doesn't cause neurotoxicity. I suspect that it increases stimulus dependent neuronal firing but inhibits all activity above a certain level. That is, it makes the stimulation "zone" smaller, possibly resulting in increased activity but reduced toxicity.
This is a wild-ass educated guess. What suggests it to me is the utility of piracetam in disorders of excitability or cell death/apoptosis-- stroke, seizures, ect. That it helps prevent further damage while enhancing cognition suggests to me that it may raise signal to noise ratio (stimulus dependent firing) while reducing or placing an upper limit on overall activity.
Its remarkable harmlessness also suggests, to me, that if it played a large role in inducing excitotoxicity, it would be more apparent on its own. This is not necessarily true, but it's my gut instinct (and an instinct only).
u/MisterYouAreSoDumb · Ceretropic
I would tend to agree with that assessment. Though subjectively, I do not like the feeling of dopaminergic stimulants with any of the racetams. I do not feel as though damage was being exacerbated, but it definitely gives me irritability. I prefer voltage-dependent NMDA receptor antagonists like magnesium and inositol to manage excitotoxicity and tolerance. Memantine being the ideal one to use for tolerance reversal.