Comment · Mon, November 5, 2012 · Ceretropic
Piracetam and psychostimulants
Original post in this thread
gannons · 23 points
http://www.sciencedirect.com/science/article/pii/S030698771200206X
So from what im reading hear is the Piracetam increases the effects of MDMA and Meth. Could one safely say that you would notice an increase effect of Ritalin while on piracetam?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
Piracetam is known to increase the density and permeability of NMDA receptors in the hippocampus and acetyl-choline receptors in the frontal cortex. This potentiates the activity of glutamate, potentially causing a sate of excitability. I stop short of excitotoxicity due to it's function as an allosteric modulator. However, that does not mean it's effects are all wanted. There is no doubt in my mind that piracetam potentiates MDMA and amphetamine based stimulants, as I have personally experimented with many combinations. However, with primarily dopaminergic stimulants like amphetamine, it causes a state of irritability with me. This anecdotal result fits perfectly within the studies that show increased glutamate activity at the NMDA receptors. So yes, it definitely potentiates it, but I do not personally like the feeling. Now on to MDMA. Since MDMA has a much lower affinity for DA and much higher affinity for 5-HT, piracetam's effects are slightly different. It still potentiates MDMA's activity. However, it does not cause the same irritability shown in the more dopaminergic drugs. It makes your roll slightly more lucid, which can be enjoyable to some, and annoying to others. I find that it slightly kills the empaty of the experience. I've settled on not taking any nootropics before my roll, then taking some before bed and the following week. This seems to be the best results for me. You also have to take into consideration whether this is an attack dose before the roll, or if you have been taking piracetam long term ahead of your roll. Long term administration of piracetam will be more likely to increase your NMDA receptor density than an attack does would. An attack does will have mostly a positive allosteric modulation effect at your AMPA and NMDA receptor sites.
Some more reading:
_______________________________________________
http://www.sciencedirect.com/science/article/pii/S0006295298002950