Comment · Sun, November 4, 2012 · Ceretropic
No effect from most nootropics
Original post in this thread
ieatcarrots · 15 points
Hi there,
I have been experiencing with nootropics and various substances for about a year and got mostly no effects.
-Piracetam. Oxiracetam, Aniracetam : no effect at all. Been using them for at least 2 weeks each at proper doses. Currently using Prami.
-Noopept : I am on it right now, I use powder form and not quite sure about dosing, althought I definately have taken much more than it is recommended. Tried both oral and sublingual administration, with or without food.
-Theanine with caffeine : I get effects from caffeine alone (who doesn't?) but got no effect from adding theanine. Shame, so many godlike reviews.
-Centrophenoxine (better version of DMAE), sulbutiamine, mucuna pruriens : No effects expect that sulb makes me a bit serious and I get angry easy.
The only substances I get effects are PEA and hordenine.
I am not sure why is this happening. Maybe it's my age (I'm 21) but not sure.
EDIT : I just remembered that I also had very good results with SNS focus xt http://www.seriousnutritionsolutions.com/products/core/Focus-XT.php
Could it be the huperzine or vipocetine?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
I have always wondered what could be the root cause for anecdotes like this. Is there something different with your receptors that alters the selectivity of the drugs you take? Does your brain down-regulate quickly to try and maintain homeostasis? The issue I have is that we are talking about many different receptors, and many different systems. The only common denominator in all the instances is one thing, your blood brain barrier. Nobody ever brings it up, but could perhaps your lack of results stem from your blood brain barrier being less permeable?
http://www.paul-tofts-phd.org.uk/CV/reprints/B48_ToftsandKermode-mrm1991.pdf