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Behind the Scenes at Nootropics Depot: Inside Our Pharmaceutical-Grade Testing Labs 🧪

Replying to AAAUUUUAUAUAUUAUA · Whoopsie. Yeah thats what i ment, your 1:1. Im very surprised that the Amyloban is that "one sided". It really does not look like it, no clue if i can blame the wobbly baseline or …

>Thats very interesting. I just did a quick google search and it does not seem to be very soluble in ethanol, it was about 0.5-1 mg/ ml in what im presuming to be 95% EtOH AND it seems to be very prone to oxidation. The patent, if i remember correctly, states that the raw materia…

Curious on y'alls thoughts on this. I spoke to a ayurveda person (ayurveda is where Ashwagandha and Bacopa come from) and he was like for thousands of years we put the herbs into food and ate it long-term and not made extracts out of it. Should we have skepticism over extracts with this logic maybe?

Replying to Warren_sl · To be fair L-BAIBA is behind the Mitoburn name which may hurt it more than help. I’m a fairly knowledgeable customer and I honestly didn’t even remember that it was that product un…

That's true. Maybe we should change the product name to just L-BAIBA instead.

Curious on y'alls thoughts on this. I spoke to a ayurveda person (ayurveda is where Ashwagandha and Bacopa come from) and he was like for thousands of years we put the herbs into food and ate it long-term and not made extracts out of it. Should we have skepticism over extracts with this logic maybe?

Replying to DoctorBoneMarrow · Whoa, thanks! I was familiar with those supplements but not with many of the specific mechanisms you mentioned. Thanks for the info, it's truly interesting. Looking at a bit more …

L-BAIBA does seem interesting! We brought that out a while back, but it hasn't really gotten very popular. This could be a cool mechanism to highlight. It does activate astrocytes, but doesn't antagonize dopamine. It supports mitochondrial function and activates AMPK, while reduc…

Curious on y'alls thoughts on this. I spoke to a ayurveda person (ayurveda is where Ashwagandha and Bacopa come from) and he was like for thousands of years we put the herbs into food and ate it long-term and not made extracts out of it. Should we have skepticism over extracts with this logic maybe?

Replying to DoctorBoneMarrow · Thank you! >Vitamin D is deficient in a lot of people, and it affects dopaminergic signaling, so that would be an easy one to add in And deficiency is linked with more severe sym…

That risperidone study is actually pretty compelling for showing astrocyte metabolism matters in the basal ganglia. If I were targeting hypoactive astrocytes specifically, here's what I'd try: * Lion's Mane- The hericenones and erinacines directly stimulate NGF synthesis from ast…

Curious on y'alls thoughts on this. I spoke to a ayurveda person (ayurveda is where Ashwagandha and Bacopa come from) and he was like for thousands of years we put the herbs into food and ate it long-term and not made extracts out of it. Should we have skepticism over extracts with this logic maybe?

Replying to DoctorBoneMarrow · How would you hypothetically approach stuttering? The prevailing research points to hyper-dopaminergic activity in the striatum/basal ganglia (similar to Tourette's) and potential…

That's tough, because the causal mechanisms are not proven yet. Thiamine is the most studied supplement for stuttering, so that is an obvious easy one to have in there. Magnesium and L-theanine would be good for the GABA effects. I'd actually say Tauromag would be the best there.…

Curious on y'alls thoughts on this. I spoke to a ayurveda person (ayurveda is where Ashwagandha and Bacopa come from) and he was like for thousands of years we put the herbs into food and ate it long-term and not made extracts out of it. Should we have skepticism over extracts with this logic maybe?

Replying to cacklingwhisper · Yes some did milk extracts, other into ghee, others straight powder or fresh depending on the herb. I got a rare TBI, long story short feverfew extract from now foods takes away m…

I am promoting modern *science*, not modern *medicine*. I agree that the pharmaceutical industry has largely failed everyone, and so have many doctors, to be honest. It's about profit over health most of the time. Even the doctors that are not in it for the money are part of a sy…

Curious on y'alls thoughts on this. I spoke to a ayurveda person (ayurveda is where Ashwagandha and Bacopa come from) and he was like for thousands of years we put the herbs into food and ate it long-term and not made extracts out of it. Should we have skepticism over extracts with this logic maybe?

First off, saying they didn't use extracts in Ayurveda is just wrong. They even have a word for using milk to extract the plants: Ksheerapaka (or Kshirpaka). That's literally a dual extract using water and the fats from the milk to extract both the water and fat soluble compounds…

Ordering emoxypine

Replying to Ineedpalmtreeliving · Im immunocompromised so definitely immunity, then strength/endurance, cns activation, stress regulation, skin and hair health

I'd keep these: * Microzinc * Reishi * Cordyceps * Tongkat * Epicatechin * Shilajit * ALA (I'd do our OptimALA) * Hesperidin * Bacopa (I'd take our Cognance) * Gotu Kola * Polygala * DLPA * Injuv * White Jelly * Agmatine * Taurine

Research Snapshots

Replying to AJolly · That's what I like about the research snapshots, they link to the underlying studies. That's what I value, since then I can go read the source material for myself! (This is dif…

The limiting factor for our research snapshots is that our entire scientific advisory board has to review and approve everything first. They are also not just rubber stamping shit like other brands do with their "doctors and scientists" that they sign up merely as marketing gimmi…

Infinigreens is amazing

Replying to Delicious_Cream_5931 · We have a similar cheaper product here in France which is composed of 71 ingredients (12,7g per packet), some of them being : - Cordyceps, Rhodiola, Ginseng, Bacopa, Reishi, Shita…

Without knowing any more, I would say it is bullshit. You can't have 71 ingredients in a single product and have them all be intelligently formulated and dosed properly. Brands often do this as a marketing tactic. We call it the kitchen sink approach. They don't know how to intel…

Anthocyanin-fucoidan nanocomplex

Replying to Warren_sl · If only ND had a Fucoidan product that activates SIRT6

There's a reason we don't, and it is not because we can't get fucoidan. I have beta tested multiple extracts before. I've even enjoyed some of them. My issue is with the lack of science on the analytical chemistry side. I don't like making claims that I can't validate in our lab,…

Cognance Bacopa

Replying to Lazlo25 · Oh really, dopimanergics? Is there any theoretical explanation for that or is it just observation? What do you think about combining it with your high potency saffron extract?

[Serotonin 5-HT2 Receptor Interactions with Dopamine Function: Implications for Therapeutics in Cocaine Use Disorder](https://pmc.ncbi.nlm.nih.gov/articles/PMC4279075/) [Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain](https://jou…

Start of a new journey 🤘Thoughts on potential stack?

That's a really good base level stack! I would personally take the Bacopa in the evening before bed, and the rest in the AM.

Cognance Bacopa

It depends on the relative binding affinities of the 5-HT2A agonist you are combining it with, but yes. I have noticed that Cognance potentiates other seritonergics. What I have really found synergizes with it are dopaminergics, though.

Nootropics depot shilajit tested by ConsumerLabs

Replying to lewanay · Their top pick is Youtheory over ND: “Like Youtheory, Nootropics Depot also contains PrimaVie, but it is more expensive: A serving of Nootropics offering 250 mg of extract costs 6…

The youTheory capsules are 250mg like ours. They just tell you to take 2 for a dose. That's the dosing games brands play to trick people into thinking they are cheaper. If they wanted a dose to be 500mg, they should have made 500mg capsules. That wouldn't game Amazon's cost per c…

MYSAD's Stack June 2024

Replying to wavyeggs · All the while, many of the herbs and extracts you release have been around in traditional medicines for thousands of years with documented uses and contradictions.

No, don't you see... TAK-653, tropisetron, and neboglamine are much safer and more understood than something as complex as Rhodiola or Bacopa. There's other things in there! I should have known better than to engage with someone that unironically posts about his IQ in /r/Gifted.…

Study: Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury

Replying to adeptus8888 · im already taking OG cistanche 50%, erinamax and Tiger milk. interested in motor function and fine muscle control improvements as a pianist. I've noticed erinamax was particularly …

Andrographis would be one I would look into. [Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion](https://link.springer.com/a…

Relievex experiences anyone?

Replying to Nebulous_Inferno · The stack is pretty potent, but the individual ingredients are not the most potent. Bacopa 24%, Supercritical CO2 Coriander, and Shoden Ashwaghanda are all more potent GABAergic he…

We do try to formulate Natrium stacks to all be able to be stacked with each other, so we consider other stacks when formulating new ones. As our Natrium catalog gets larger, that is getting harder. However, we always try to think about what other Natrium stuff someone would be s…

⚠️ NEW PRODUCT RELEASES ARE COMING 5/9/24 | Two Mystery Products, L-Tryptophan Capsules, & Supercritical CO2 Cistanche Capsules⚠️

Replying to TheGermanGuy21 · Thanks for the reply. You mention sedation, but any idea why Cistanche might make some people feel dysphoric/depressed on it, even the next day? Reminded me of how I reacted to Agm…

Yeah, I think 5-HT1B is the most likely mechanism behind that effect you are getting. That receptor is a current target of interest in depression research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919989/ Think of our Cistanche products as a sliding scale. * Non-Extracted Ci…

Question about Microbial Test Standards

WTF is that guy on about?!? We use the limits set by both USP and the AHPA. https://ahpa.gomembers.com/Portals/0/PDFs/Policies/Guidance-Policies/Microbiology___Mycotoxin_Guidance.pdf The limit is 10,000 CFU (10^4) for extracts. The NSF limits for non-extracted botanical ingredien…

Bacopa synapsa (55%)

It's just a wrong number. Synapsa doesn't contain anywhere near that. They are using false UV-VIS numbers because they look higher. Using UV-VIS to assay bacopasides results in such incorrect numbers that I feel it's willful fraud at this point. Every brand knows the UV-VIS numbe…

Website Redesign - Feedback Needed!

Replying to Nebulous_Inferno · The ability to sort by multiple categories simultaneously for when you want to hit multiple targets. More meaningful tagging, not just "pain and inflammation", or "immunity", but…

The filtering by multiple categories and effects simultaneously is absolutely going to be a big part of the redesign. This is some of our brainstorming for structure: https://imgur.com/a/W0HloJ5

⚠️ NEW PRODUCTS ALERT | Mushroom Magic Cocoa Powder & Mushroom Magic Coffee Powder ⚠️

Replying to Feb2723 · A shroomed up take..... Who you calling cocoa. Those are terms you get when put into an AI generator to create a slogan. The cartoon coffee/hot chocolate drawing. I guess I l…

Ahh, the slogans. Got it. That's not AI. I made those all up on my own! LOL. They're just silly dad joke slogans. I put them there as placeholders, and then just decided to leave them. My team actually used ChatGPT to come up with slogans, but they were super rigid and came acros…

⚠️ NEW PRODUCTS ALERT | CistaMAX Optimized Cistanche Capsules, Dioscorea nipponica Capsules, Cistanche tubulosa Capsules ⚠️

Replying to CrimsonMax · So, I was taking it on an empty stomach and I stay fasted for like 8 hours after taking it, I'm taking it with EGCG, Berberine, Hesperidin. A few days ago I started taking Ultra Re…

Glad to hear you are getting such great results! It's really awesome when you finally find that stack that works for your individual body/brain chemistry. Our 9% reishi is really so much more potent than anything else on the market. I posted the testing table once, but I am sure…

⚠️ NEW PRODUCTS ALERT | CistaMAX Optimized Cistanche Capsules, Dioscorea nipponica Capsules, Cistanche tubulosa Capsules ⚠️

Replying to CrimsonMax · I'm happy that you guys are naming all your stacks after me, somethingsomethingMAX. I was just curious, will there be a focus stack in the near future? Something like 8:1 LM + Sab…

Yes, we have a focus stack planned, along with memory, longevity, mood, etc.