Comment · Thu, May 29, 2025 · ND Owner
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Original post in this thread
NDSocialMedia · 60 points
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What they were answering
IncreasinglyTrippy · 6 points
Much appreciated. I love when you get nerdy on the science and processes.
\> The dose we used is also below the threshold for dopamine receptor desensitization that has been seen in studies.
This is the punchline i was looking for. I vaguely remembered something about receptor desensitization, but didn't recall the details. But no surprise you guys did your homework and then some, and thought this out pretty deeply.
Very cool on the TA analysis. You seem like one of the few entities doing the "long tail" of compound analysis.
u/MisterYouAreSoDumb · ND Owner
The other issue with too much L-DOPA is dopamine oxidation, which is counteracted by the phytochemicals in Mucuna. This is why the 15% standardization is better than higher % L-DOPA ones.