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Comment · Fri, April 4, 2025 · ND Owner

From "Non-Responder" to Hyper-Sensitive

Original post in this thread

Domingo_salut · 10 points

When I started my supplement journey, 6 years ago, I just had sobered up and I couldn't really discern any effects from what I was experimenting with. Being used to hardcore drugs and binge drinking, those little legal powders were getting down unnoticed. I was just happy to do something good for myself.

Over time, I got better at noticing how stuff was affecting me. I realized Ashwagandha and Tongkat were not for me. I had my staples and continued playing around testing more herbs and minerals...

About last year, I tried a few different herbs that didn't do it for me. One after the other, they all got me pretty bad side effects. It tends to be one of 3 things: either they mess with my sleep, either they give me anhedonia/brain-fog or either they trigger my headaches. With a few like Reishi and Turkey Tail, I fall asleep no problem but wake up way too early. Now Ginko, that has always been a staple of mine, just did the same thing to me after only 2 days of dosing at the recommended dosage. On top of that, I felt a bit of anxiety from it, from basic Ginko!

Now, I know I sound like an anxious person but the truth is I am not really. I think my body got overly sensitive to suppl…

What they were answering

Goh77 · 1 points

Hey, sorry to jump in here. Any clue why I've been getting super angry and aggressive lately whenever I take gabaergic compounds, mainly Kava or Phenibut? It's been happening the past few months, even though I barely use them, maybe once every two months sometimes more. I didn't this issue before, and I don't drink or take any drugs or medications. Weird, right?

u/MisterYouAreSoDumb · ND Owner

Kava has MAOI properties, which can push you too far into agitation sometimes. Phenibut can also down-regulate GABA receptors. When paired with the MAOI effects of other compounds, this exacerbates the potential agitation.

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Commentr/NootropicsDepotOct 19, 2021

Agmatine, Piracetam, Kava and Phenibut arrived to Germany

It probably helps that we moved to Asendia, which clears the packages in France and the Netherlands instead of Germany like DHL Ecommerce did. German customs are always horrible to deal with.

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Commentr/NootropicsDepotOct 23, 2021

[deleted by user]

Replying to tunapastamayo111222 · Strange effects for me, there a component i like usually about 2 hours after ingestion that lasts 1-2 hours where theres a noticable reduction in anxiety and slight mood lift. Howe

Kava has MAOI effects, which explain the variability. Those MAOI effects will alter you reaction to the other stuff you are taking at the same time.

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Commentr/NootropicsDepotSep 24, 2021

⚠️ NEW PRODUCT ALERT | High Bioavailability Noble Kava Tablets | 1,000mg | Minimum 10% Kavalactones | Enhanced Traditional Water Extract⚠️

Replying to Fightochemical · Are you shipping this product to the UK? I did try to order Kava powder before from the US and it was seized. But a Kava supplement in capsules from some other country in Europe ca

We are not restricting it to the UK at this time. We'll see how things go and assess if we have issues. We rarely have issues with the UK, and we ship many packages every single day there. There have been some limited is

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Commentr/NootropicsDepotJan 21, 2021

I miss piracetam :(

Replying to vvvv555 · Good news! I'll have to ration it better this time. Do you recommend anything on your site similar to kava or phenibut that can be used as an alternative to alcohol?

Magnolia bark might be one you look into.

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Commentr/NootropicsDepotJun 27, 2020

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Replying to Majalisk · You think doing that, even a half dosage, could wreck some people’s tolerance toward things like kava or phenibut, or would that not be in the plausible realm? Not just asking abou

I don't think so. I have taken a 500mg lemon balm tablet every night before bed for months now. Last night I made some kava tea with rooibos and passed out on the couch. LOL. So at least for me it did not affect my toler

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Commentr/NootropicsNov 29, 2013

Best time to take phenibut?

Replying to JoocyDeadlifts · Would love to hear more if you have time to kill. I love me some phenibut, but I don't dare take it more frequently than 1x/7-10 days, so I've been looking for something with simil

Kava could be an option for you. It up-regulates GABA-A receptors. It actually sensitizes over time, rather than builds a tolerance. Ashwagandha is an adaptopgen, and helps modulate your GABA system without building tol

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