Comment · Mon, May 20, 2024 · ND Owner
Study: Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury
Original post in this thread
MisterYouAreSoDumb · 36 points
We found a study on acteoside (verbascoside) from Cistanche that is really interesting!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599386/
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I'll copy the abstract below, and some highlights I found particularly cool.
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Chronic spinal cord injury (SCI) is difficult to cure, even by several approaches effective at the acute or subacute phase. We focused on skeletal muscle atrophy as a detrimental factor in chronic SCI and explored drugs that protect against muscle atrophy and activate secretion of axonal growth factors from skeletal muscle. We found that acteoside induced the secretion of axonal growth factors from skeletal muscle cells and proliferation of these cells. Intramuscular injection of acteoside in mice with chronic SCI recovered skeletal muscle weight reduction and motor function impairment. We also identified pyruvate kinase isoform M2 (PKM2) as a secreted factor from skeletal muscle cells, stimulated by acteoside. Extracellular PKM2 enhanced proliferation of skeletal muscle cells and axonal growth in cultured neurons. Further, we showed that PKM2 might cross the blood–brain b…
What they were answering
trvbone · 1 points
Ok so please help, looking for advice to help my wife. She's got a couple vertebrae out of whack.
So I'm seeing cistanche and tigers milk are good options for spinal cord injury would my wife's issues be in the same category?
Basically you know how your spinal cord is supposed to curve in towards your belly button right before your butt two of her vertebrae are set back right after the curvature is supposed to start.
Doctors believe it's from improper core strength or working out without considering proper form.
She used to kickbox a lot as a great stress relieving tool and was told she should stop or she'll be in a wheelchair eventually.
She's been doing physical therapy and it's helping but I don't think it's going to just put things back in place magically.
She's trying to avoid surgery for as long as possible.
Any input, advice or suggestions would be awesome!
u/MisterYouAreSoDumb · ND Owner
That's a tough one. Most people here wouldn't be qualified to give that type of medical advice, especially considering the seriousness of the injury. Spinal issues are no joke, and can go south very quickly. Getting those vertebrae back in place needs to be step one in my opinion. All the other issues stem from them being out of place, so trying to mask that is just masking symptoms.