Comment · Thu, August 25, 2022 · ND Owner
🔬Share Your Research Studies! Weekly Wednesday Discussion Thread🔬
Original post in this thread
NDSocialMedia · 12 points
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We like our studies verified, not forged! Each Wednesday, we round up our favorite research study discoveries to share and discuss with the community on r/NootropicsDepot. Discover new studies, dig deeper into research, and present your findings from research studies about supplementation, nootropics, health, and fitness here on our weekly discussion thread.
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · ND Owner
mCPP is a non selective 5-HT receptor agonist displaying affinity for the 5-HT2 family receptors which consists of three subtypes, namely the 5-HT2A, the 5-HT2B and the 5-HT2C receptor. Functional characterization on recombinant human receptors showed that, compared to 5-HT, mCPP has a higher affinity for the 5-HT2C receptor with respect to the other receptors of the 5-HT2 family receptors [16]. Excessive self-grooming induced by mCPP was reversed by the selective 5-HT2C receptor antagonist SB-242084, but not by the selective 5-HT2B receptor antagonist SB-215505. These results provide evidence that the mCPP-induced exaggerated grooming is mediated, at least, by activation of the 5-HT2C receptor [4]. In this context, the present findings suggest, that crocins might alleviate the mCPP-induced excessive self-grooming by an antagonistic action at the 5-HT2C receptor site.
Crocins from saffron might be 5-HT2C antagonist like agomelatine!