Comment · Wed, February 9, 2022 · ND Owner
What's the reasoning for Agmatine to have a serving dose of 250mg?
Original post in this thread
fuck17685 · 17 points
At that point would it even effect NMDA receptors? Is the serving dose moreso for people looking for enegery/gym pumps? Or is it just for safety/legal reasons?
I'm looking to use it for gulatamate modulator.
What they were answering
fuck17685 · 2 points
Thanks so much for the responses!
Hope you don't mind two more questions
Have you tried higher doses?
And if you don't mind me asking bcuz this is more personal question, what substances are you using for Agmatine to mitigate tolerance?
Also what do you make of Agmatine accumulating in the brain? (Assuming I interpreted this correctly)
https://pubmed.ncbi.nlm.nih.gov/10785653/
Agmatine is synthesized in the brain, stored in synaptic vesicles in regionally selective neurons, accumulated by uptake, released by depolarization, and inactivated by agmatinase.
Also just for fun, do you use old.reddit.com or the redesigned one? :D
u/MisterYouAreSoDumb · ND Owner
I have used higher doses. It just amplifies the side effects for me. This would be making sleep worse, reducing motivation during the day, and sapping energy. It can bind to the a2A-adrenergic receptors in higher doses. Everyone is different, but finding the right dose for daily use is key. My tolerance use for it is for kratom.
Also what do you make of Agmatine accumulating in the brain? (Assuming I interpreted this correctly)
Accumulate in that context is not a negative thing. It's not like aluminum accumulating in the brain. That is just saying that you can supplement it, have it pass the BBB, then accumulate in the neuronal stores where it can be used later.
https://sci-hub.se/10.1016/s0165-6147%2800%2901460-7
Also just for fun, do you use old.reddit.com or the redesigned one? :D
I have one screen on old Reddit and one on new. I mostly use old because I have been here so long, and that is what I am used to. The vast majority of people use new Reddit, mobile, or the app now, though. We have designed this sub around new Reddit. It does have a lot more features than old.