Comment · Sun, January 30, 2022 · ND Owner
andrographis reactions
Original post in this thread
phaedrus_ravenscroft · 8 points
Really want to try andrographis but I keep reading about bad reactions from it. Is it safe? Anyone have any negative experiences.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364323/
https://www.medsafe.govt.nz/safety/ews/2017/AndrographisPaniculata.asp
What they were answering
Volcanyx · 1 points
Okay, if I find time I will give it a listen. Off topic, but something else I was very curious about was if you have ever considered producing Anandamide? It is seemingly a good fit with ND with other substances that engage the endo cannabinoid system like Rephyll, Palmitoylethanolamide, Oleamide. Would there be anyway this could become a thing?
u/MisterYouAreSoDumb · ND Owner
Anandamide doesn't work when taken orally. This is why things that prevent the breakdown of endogenous anandamide, like FAAH inhibitors, work better. That being said, it looks like encasing it in hydroxypropyl-β-cyclodextrin could get around that.
https://sci-hub.se/10.1016/0378-5173%2896%2904522-x
We are installing some new equipment on our gas chromatograph to better analyze fatty acids. Once that is in, we will be expanding our fatty acid line. I just wanted to hold off till we could properly test them in-house. Anandamide encased in hydroxypropyl-β-cyclodextrin would be similar to Rephyll, so that could be a promising one.