Comment · Tue, April 13, 2021 · ND Owner
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Original post in this thread
NootropicsDepotCom · 17 points
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What they were answering
allthethrowaway420 · 1 points
So that paper says this: “ our findings show that the addition of silymarin to BBR is able to improve its positive effect on lipid and glucose metabolism in humans, allowing for the administration of lower doses of BBR and accordingly reducing the associated risk of gastrointestinal discomfort which is demonstrably dose related “
They reduced the daily dose from 1500mg to 1000mg or 500mg when they added silymarin. I wanted to ask if you have any numbers for how much silymarin increases bioavailability (I didn’t see a comparison of the BBR silymarin 1000mg combo to 1500mg of just BBR in the paper). Clinical benefit is proven at 1500mg, but I don’t know how much mg a day is needed for the combo to get the same benefit. I’ve been taking 1500mg a day and my stomach is on fire
u/MisterYouAreSoDumb · ND Owner
I don't think we can give an exact number/ratio for it. However, the studies in that meta analysis used 500mg/day and 1,000mg/day. Both of them showed positive study outcomes. I personally use 500mg/day. You could always drop down to 1,000mg/day and see if your stomach improves. Split it into tow 500mg doses.