Comment · Tue, February 2, 2021 · ND Owner
Phosphatidylserine suggested use seems incorrect?
Original post in this thread
prl853 · 13 points
ND's Phosphatidylserine page seems to suggest using one softgel per day, but one softgel is merely 100mg while the dosing regimen used in the studies were 100mg 3x per day.
https://nootropicsdepot.com/smart-ps-phosphatide-complex-softgel-capsules-100mg-phosphatidylserine/
Also, on that note, it is one of the priciest supplements on the entire website if one intends to take 100mg 3x per day which is a shame since I'd like to try this supplement and would prefer to purchase from ND if possible. Might it be because it is a branded product?
What they were answering
derpderp3200 · 2 points
Ah. What's the benefit of supplementing Phosphatidylserine in general? What role does PS play in the human body, overall?
E.g. I know that Lysophosphatidylcholine is a major carrier molecule for getting EPA and DHA into the brain^1, and a bit below half of Phosphatidylcholine-conjugated EPA/DHA gets delivered into the brain, as per the same study, with IMO EPA being preferred as per this study^2 demonstrating it enriches both EPA and DHA adequately, with rapid and efficient conversion. IIRC, EPA also plays its own roles, and is the body's native way of getting DHA into the brain, rather than DHA being transported directly. It mentions a synthesis method, too.
LPC-EPA is a huge wishlist thing for me, so if you would be interested in looking into it I would be delighted. There's a bunch more studies linked by a person in this thread, though I've not read the rest of them.
As far as I can tell, I think that indirect augmentation of LPC-EPA synthesis is what all the UMP+Choline+omega3, CDP-Choline, etc. combos do, except not as efficiently and with marked cholinergic(and possibly other) side effects.
^1 [Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: Lysophosphatidylcholin…
u/MisterYouAreSoDumb · ND Owner
PS has a cortisol regulating effect in humans. It also lowers ACTH in response to stressful situations., along with a number of other neuroendocrine responses.
Effects of Phosphatidylserine Supplementation on Exercising Humans
Effects of Phosphatidylserine on the Neuroendocrine Response to Physical Stress in Humans
Effects of Phosphatidylserine on Exercise Capacity during Cycling in Active Males