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Comment · Fri, June 26, 2020 · Natrium Health & Nootropics Depot

Lion's mane 8:1 extract, empty stomach or with food?

Original post in this thread

wormant1 · 1 points

I got ND's 8:1 extract and would like to know if I'll get the most benefits by taking it on an empty stomach or with food.
I was told alcohol-soluables are best taken with food while water solubles need to be taken on an empty stomach.

In that case, wouldn't a dual extra be counterintuitive since the optimal absorption of one part interferes with the absorption of the other?

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

Empty stomach is best. It makes zero sense to promote taking food with alcohol-soluble things. Using ethanol in the extraction process is meant to concentrate the compounds soluble in those things. Trying to reduce the complex pharmacokinetics in the human body based on simple solubility just doesn't work. Very few things are better absorbed with food. 90% of the time empty stomach is best. The stuff you read/hear online is wrong most of the time. If you look at the specific molecule you are interested in, and the LogP is over 5, then maybe dissolving it in an oil would improve absorption. Even then, that's reducing the complexity too much. Just default to empty stomach, and you will be good the vast majority of the time.

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