Comment · Mon, April 27, 2020
7,8-dhf and Piperine
Original post in this thread
BioKrab · 5 points
I’m just curious as to if 7,8-dhf absorption is increased by Piperine? I did a little research and was unable to find an answer as to what enzymes metabolize 7,8-dhf. Also, if it matters I use 7,8-dhf sublingually.
What they were answering
Cordyceptual · 1 points
I agree with MYSAD. Piperine would help increase the level of 7, 8 DHF in its aglycone form since piperine inhibits glucuronidation of flavonoids. A chemical very similar to 7'8'-DHF is Baicalein which is increased piperine. Flavonoids for the most part, would be increased by piperine not just by P glycoproteins but also preventing it from being metabolized into less potent conjugates .
Curious if the 7'8'-DHF from ND has a sugar moiety (glycone) attached or if it's in it's aglycone form without sugar. I work with flavonoid pharmaceuticals and would love to know if the 78DHF is still absorbed as well and stable in blood stream as 78DHF with the sugar moiety still attached. Reason being that the microbiome does take part in flavonoid absorbtion, metabolism, re-absorption and elimination for most but not all.
[Overview of Metabolism and Bioavailability Enhancement of Polyphenols]
u/MisterYouAreSoDumb
If it had the sugar moiety, it would not be 7,8-DHF. Is there even a name for the glucoside of 7,8-DHF? The glucoside of tyrosol is salidroside. Quercitrin is the glycoside of quercetin. So when something is in a glycoside form, it is given a different name. The same would be true of 7,8-DHF. I will look into the possible glycoside versions that could be made, and see if there is any promise there.
Thanks for the paper! It does appear that piperine might positively affect 7,8-DHF after all.