Comment · Tue, April 21, 2020
Original post in this thread
BioKrab · 5 points
I’m just curious as to if 7,8-dhf absorption is increased by Piperine? I did a little research and was unable to find an answer as to what enzymes metabolize 7,8-dhf. Also, if it matters I use 7,8-dhf sublingually.
What they were answering
daninnoke · 3 points
What are you worried about?
u/MisterYouAreSoDumb
Bears
Comment · Tue, April 21, 2020 · 3 pts
7,8-DHF is a weak substrate for P-glycoprotein. So piperine might help some, but probably not a ton. Schisandra chinensis is another P-glycoprotein inhibitor. I know everyone likes to refer to that mouse study showing it
Comment · Tue, April 21, 2020 · 2 pts
I mean, it could be playing some role. It might be keeping it in the brain longer, as P-glycoprotein is what usually pulls things back out of the CNS.
Comment · Tue, April 21, 2020 · 3 pts
LOL, I guess my wording was confusing. P-glycoprotein is not really a big issue for the bioavailability of 7,8-DHF like it is with something like curcumin. So I would not be worried about inhibiting it to improve 7,8-DHF
Comment · Mon, April 27, 2020 · 2 pts
If it had the sugar moiety, it would not be 7,8-DHF. Is there even a name for the glucoside of 7,8-DHF? The glucoside of tyrosol is salidroside. Quercitrin is the glycoside of quercetin. So when something is in a glycosi
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