Comment · Sun, April 5, 2020 · Natrium Health & Nootropics Depot
A cohort of cancer patients with no reported cases of SARS-CoV-2 infection : the possible preventive role of Methylene Blue
What they were answering
AlaskaTuner · 2 points
I’m not sure, but the quality of their warez was second to none.
he main difference was QC, in-house lab, and the community involvement of u/misteryouaresodumb
I still have a bit of ceretropic phen and the taste, effect is so different from what nootropicsdepot sells today. There might just be batch-batch variance, but that OG ceretropic phen was so much better than anything else on the market it was like a completely different drug.
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Synthesis pathways changed. It led to a more pure product, but we think the polymorphs changed. The crystal structure can affect how well something absorbs in the body. So you can compare two pure batches of phenylpiracetam, but one will absorb better than the other because of the crystal structure. You need to use X-ray crystallography to see the difference. Chemically they are the same. It's a physical difference in the small crystal particles. Pretty nuts when you get into it. Look into the pharmaceutical industry and how they closely control crystal structures and polymorphs. This could be a big explanation for why some brand name drugs just work better than the generics. It's not purity, it's polymorphs.
Phenylpiracetam was banned in China. So no more from there anyway. We are ramping up our own synthesis labs in other countries now, and we are going to specify synthesis pathways and final crystallization steps. So we are going to closely control things. We actually did that on our last couple batches of adrafinil. We had the labs synthesize it our way, and had them do specific final purification steps. The only way you can do that is to pay for the full synthesis yield ahead of time, which was hundreds of thousands of dollars for a single batch. So we are likely the only ones in the world doing that for some of these nootropics. Everyone else just gets what they can find available. We are big enough now that we are starting to control the synths ourselves, and we are working to use some of the lessons the pharma industry has learned to make things better. This shit is super complex, though. This is not basic chemistry. It's not even really chemistry. It's materials science, and the pharma companies keep a lot of what they know as trade secrets.