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Comment · Thu, December 26, 2019 · Natrium Health & Nootropics Depot

HA-966 HCl - Atypical sedative, and neuroprotective antagonist at the glycine modulatory site of the NMDA receptor complex, anyone have any info on this newly available substance?

Original post in this thread

StolenSpirit · 51 points

From Wikipedia I found:
"HA-966 or (±) 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist / low efficacy partial agonist. It has neuroprotective and anticonvulsant,[1] anxiolytic,[2] antinociceptive[3] and sedative / hypnotic[4] effects in animal models. Pilot human clinical trials in the early 1960s showed that HA-966 appeared to benefit patients with tremors of extrapyramidal origin.[4]

The two enantiomers of HA-966 have differing pharmacological activity. The glycine/N-methyl-D-aspartate receptor antagonist activity is specific to the R-(+) enantiomer, whereas the sedative and ataxic effects are specific to the S-(-) enantiomer.[5]

R-(+)-HA-966 did not induce drug-appropriate responding in animals trained to discriminate phencyclidine (PCP) from saline, suggesting that the glycine receptor ligand R-(+)-HA-966 has a significantly different behavioral profile than drugs affecting the ion channel of the NMDA receptor complex.[6]

S-(−)-HA-966 has been described as a "γ-hydroxybutyric acid (GHB)-like agent"[7] and a "potent y-butyrolactone-like sedative",[5] but it shows no affinity for the GABAB recept…

What they were answering

srubek · 2 points

Of course

Harm reduction is #1!

Thank you bud

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

My pleasure!

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