Pain Management

7,8-dihydroxyflavone

BDNF as a pain modulator.

I'll ask my product specialist the specifics of why he put 7,8-DHF under that category to confirm.

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Triacetyluridine

Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin

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Berberine

Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome \(IBS-D\) Symptoms in an Opioid-Receptor Dependent Manner

In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain. In physiological conditions the effects of berberine were mediated by mu- (MOR) and delta- (DOR) opioidreceptors; hypermotility, excessive secretion and nociception were reversed by berberine through MOR and DOR-dependent action. We also found that berberine increased the expression of MOR and DOR in the mouse bowel and rat fetal cortical neurons.

Berberine significantly improved IBS-D symptoms in animal models, possibly through mu- and delta- opioid receptors. Berberine may become a new drug candidate for the successful treatment of IBS-D in clinical conditions.

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Red Reishi

Effects of Ganoderma Lucidum on Pain in Women with Fibromyalgia

Effect of Ganoderma lucidum on postherpetic neuralgia.

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NextCBD - does this offer any advantages over the stated equivalent amount of normal CBD? So it says 10mg is equivalent to 200mg CBD, how was this equivalency measured?

It's a nanomicelle formulation of CBD that drastically increases the bioavailability of CBD. It was developed and studied by ANANDA Scientific in Israel.

* "Secret Sauce" seem to be nano-micelles
* All About Nano-Micelles
* PubMed explaining how/why micelles work for CBD delivery
* CBD absorption with micelles
* Cannabinoids and micelle deep dive

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Sarcosine - so it looks like this can act on the NMDA receptors, has there been any actual studies on the pain relieving properties or is this just theoretical at this point?

Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

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Palmitoylethanolamide - are there any special variants of this (like with curcumin that can increase bioavailability), or would it be about the same no matter where you get it? I tried Vitalitus Palmitoylethanolamide which didn't seem to help, would ND's product be any different?

I have not tested their stuff. Perhaps I should. So I can't say if you would react to ours if I don't know if theirs is even legitimate. I will say that PEA shines in combinations. So combining it with curcumin/Longvida, CBD, emoxypine, and oleamide makes for a much more effective stack than it on its own.