Comment · Thu, July 4, 2019 · Natrium Health & Nootropics Depot

Does Polygala affect serotonin in any significant way?

Original post in this thread

mlp275 · 1 points

Examine.com indicates its active components (Yuanzhi-1 particularly) inhibit SERT and are equipotent to fluoxetine. Particularly speaking about the ND extract, is this applicable to oral administration? Is the level of Yuanzhi-1 known for this specifiic extract?

Examine.com also says that in nice polygala fails to influence age-related decline in hippocampal serotonin. Another study showed that other constituents of the herb (polygalasaponins) actually have anti-serotonergic effects.

I don't believe there is any more research on the topic, especially not in humans. Has anyone noticed any interactions between the herb and other drugs with effects on serotonin? Particularly curious if it's effects on SERT are strong enough to block the effects of psychedelic drugs.

What they were answering

mlp275 · 3 points

u/MisterYouAreSoDumb I highly value your opinion if you don't mind to chime in.

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

No, it more affects ACh, glutamate, cortisol, and oxidation.

Other MYASD lines in this thread

Comment · Tue, July 9, 2019 · 1 pts
More so the low concentrations. We want to do a higher Yuanzhi-1 extract, or a synthetically pure version of it. That is just harder than it seems. There are no reference standards for it. So confirming its presence and

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