Comment · Thu, November 22, 2018 · Natrium Health & Nootropics Depot
Does Emoxypine Repair and Reverse Brain Damage from Alcohol Abuse?
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scott_sebastian · 77 points
I have frequently read online that Emoxypine (also known as Mexidol) possesses the ability to repair and reverse brain damage from previous alcohol abuse.
People who affirm this effect usually refer to the following section of this study:
Anti-alcohol action. Mexidol has a pronounced anti-alcohol action exerting a therapeutic effect on the disorders caused by chronically used ethanol, on the abstinence syndrome and the acute alcohol intoxication. Within the chronic experiment young eugamic mice (females) beginning with the age of three months have been used 15% ethanol solution instead of drinking water for 5 months. The amount of ethanol used by one mouse in a day was 0.56-0.75 ml (absolute alcohol equivalent). Mexidol was used simultaneously with ethanol in the dose 20-25 mg/day. The examination of the animals' behavior 2 weeks after the 5-month ethanol introduction revealed significant and statistically reliable worsening of learning and memory abilities during the development of active avoidance reflex in the shuttle box. Animals performed a lot of wrong reactions, there were fewer number of co…
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Billynabs · 1 points
Can you explain what you mean by "binding affinity of GABA". Would this help with people that may have desensitized GABA receptors from alcohol/benzos/phenibut?
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
It likely does it through either an allosteric binding site, or indirectly through other mechanisms. I found that information in a Russian study about it.
So it does not have any direct affinity for the GABA or benzodiazepine sites, but does increase their binding. This could certainly help people with desensitized GABA receptors.