Comment · Tue, May 30, 2017 · Ceretropic & Nootropics Depot
Serotonin antagonism to improve memory?
Original post in this thread
bob000000005555 · 8 points
I've anecdotally noticed that when I'm working on a cognitively demanding task, especially when collaborating with others, that SSRIs prescribed for anxiety seem to impair my memory. In fact, according to https://www.ncbi.nlm.nih.gov/pubmed/17092965, "Escitalopram showed an impairing effect on immediate verbal recall which nearly reached statistical significance." In undemanding situations I didn't notice it. But it's profound enough when noticed that I've decided to stop taking it. This has subjectively led to cognitive gains.
This led me to consider what would happen if a serotonin antagonist were used instead.
From what I've gathered, certain serotonin receptors are associated with memory impairment: according to "Role of serotonin in memory impairment", "5-HT1A or 5-HT3 and 5-HT1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand."
Here is a link to Google Scholar results for "serotonin and memory", alon…
What they were answering
bob000000005555 · 1 points
Thank you.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
No problem!