Comment · Mon, March 6, 2017
Buy fasoracetam and become addicted to that instead of Phenibut (no withdrawal, long term anxiety treatment that becomes stronger every day)
Original post in this thread
siedow · 11 points
This is just my theory. People who have experience with 50mg+ daily doses of fasoracetam in the long term? (>1 month)
Phenibut acts as a selective GABAB receptor agonist and as a blocker of α2δ subunit-containing voltage-gated calcium channels, similarly to gabapentin and pregabalin. The desired effects you get are relaxation and motivation, starting from 2 hours after dosing. The problem: you become tolerant, your GABA and dopamine system becomes sensitive to this and downregulates.
Fasoracetam on the other hand is a chemical of the racetam family. It's not a agonist and not an antagonist at the GABAB receptor, but it is known to make more GABAB receptors in your brain (=upregulation of GABAB) and by doing this you become more sensitive to your own GABA. You don't have the 'Phenibut' feeling instantly, but in the long term you build up a similar feeling by dosing every day. You also won't get a withdrawal, but your brain will eventually return to baseline.
I haven't gone through the experiment by dosing ONLY fasoracetam, but I have dosed phenibut + fasoracetam together (when I was a Phenibut addict) and I have noticed that my tolerance to phenibut built up much slo…
What they were answering
kylekingsly · 1 points
Gotcha, that seems to be directly contrasting with what the guy I was responding to was saying...is it not true that abruptly stopping would be dangerous or unpleasant? I'm planning to stop taking almost all nootropics this summer once I don't need the regular boost as much.
I was also a little worried about the potential excitotoxicity risk when faso is combined with NMDA stimulant that /u/MisterYouAreSoDumb was describing here. I'm planning to take Curcumin (which is an NMDA agonist) on a daily basis once my Bromantane comes in to mitigate the Alzheimer's risk so couldn't that be a bad combo?
Maybe he could comment on this too because I'm a bit unclear as to whether the risk is significant or not.
u/MisterYouAreSoDumb
I would not personally worry about interactions between curcumin and fasoracetam. My caution was more for stronger AMPAkines.