Comment · Tue, October 25, 2016 · Ceretropic & Nootropics Depot
Polygala Tenuifola Acute vs. Chronic Effects?
Original post in this thread
Luchadorgreen · 12 points
TL;DR: What is the relationship between effects of acute and chronic Polygala Tenuifolia administration?
So I recently received this noot from ND, and it is so effective it is scary. I noticed a decrease in brain fog and a small increase in motivation and mood, which I severely needed. I am able to put in hours of study time in, even after work, which normally leaves me close to brain-dead. Can someone smarter than I explain these effects to me?
I saw a couple studies that indicated that it could provide significant cognitive benefits dosed several times a day for a few weeks. However, it is my understanding that most substances with awesome acute effects rarely offer long-term benefits. Why wouldn't there be some sort of down-regulation mechanism curtailing the benefits of long-term administration? Has anyone seen studies on administration going past four weeks? Is there anything that should indicate that I should cycle it? Also, does anyone know how it might interact with bacopa?
Sorry to ask you guys to do the legwork in explaining this, I just don't have time to become a neurochemistry expert and there is still a lot I don't know about the brain and about this herb.…
What they were answering
samlljc · 3 points
Thanks for the reply! I see what you mean about it being complicated. But based on what we know thus far, do you think it is reasonable to say that chronic doses of around 100mg per day should probably be safe and well tolerated?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Based on what we know, yes it seems safe and well-tolerated. I am doing a long-term trial of it right now, in fact.