Comment · Fri, June 10, 2016
status of 7,8-dihydroxyflavone ?
Original post in this thread
lorrieh · 1 points
I know that MrY mentioned a few months ago that his samples didn't match the Sigma-Aldrich reference samples, and he didn't feel comfortable selling this compound until he could explain the discrepancy.
so where are we on that?
What they were answering
BioChemistryStudent · 1 points
Reason I brought it up, was that so far as I am aware, the cerotrophic effect of these flavones is through TrkB; so at the end of the day; so long as it binds TrkB, mimicing BDNF, it should work... right?
Do a head to head comparison between your source, and sigma's product, and if they are comparable, why not sell it as a flavone TrkB agonist?
u/MisterYouAreSoDumb
Well the relative affinities, pharmacokinetics, and other affinities play a role in the effects too. It's not just about activating TrkB in general. Just look at the differences in effects between LSD, Mescaline, and Psilocin. They are all 5-HT2A agonists, but have other affinities and effects along with it.
Do a head to head comparison between your source, and sigma's product, and if they are comparable, why not sell it as a flavone TrkB agonist?
Sigma does not give enough for anything other than analytical testing, and I will not sell a compound unless I know exactly what it is, and how pure it is. Without knowing the compound, there is no way to know the purity.