Comment · Wed, May 25, 2016 · Ceretropic & Nootropics Depot
SEMAX/NOOPEPT Intranasal effectiveness
Original post in this thread
rkb83 · 1 points
Recently got these from Ceretropic, not sure if this was the right mode of administration for me..My nose is blocked most of the times due to allergies and i think i lost sensitivity since my sense of smell has comedown pretty much to the bottom. Would these still be effective if i use the nasal sprays? i'll sneeze after 10 mins of using this , so i'm concerned if any of this is getting through..I also use another inhaler for allergies..should i use them subcutaneously ? or is this fine?
What they were answering
the_flisk · 1 points
SubQ is extremely easy to do, has 100% bioavailability and there are no issues with spray "priming", stuffed nose and other problems that come with nasal spray.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Another thing to consider is that Semax showed pain relieving effects when injected peripherally, but did not show it when taken nasally. However, the memory enhancing effects of Semax were more pronounced nasally. This could be why some people prefer one method over the other.
The Nootropic and Analgesic Effects of Semax Given via Different Routes
The results showed that i.p. Semax had nootropic and analgesic actions. Dose-response characteristics were different for these different effects. Intranasal Semax was more effective in improving learning in animals than i.p. Semax but had no effect on pain sensitivity. Our results provide evidence that different mechanisms and brain structures are involved in mediating the nootropic and analgesic effects of Semax.
So sub-Q compared to intranasal has more implications than just bioavailability.